Contrary to popular beliefs, the incidence of prostatitis identified and confirmed by laboratory tests is about 9%.However, inflammation of the prostate gland is often recurrent or chronic.
The prevalence of chronic forms of prostatitis, characterized by inactive inflammation and small clinical symptoms that reduce the quality of life, is difficult to evaluate.
In addition to acute and chronic bacterial prostatitis, chronic pelvic pain syndrome is distinguished separately, where leukocytes are detected in the third part of the urine or seminal fluid, as well as chronic pelvic pain syndrome without changes in inflammation.
In the occurrence and maintenance of symptoms of chronic prostatitis, urinary tract impairment, expressed in high urinary pressure, intraprostatic reflux that forms rough urine flow, pathogenic effects of microorganisms, immunological reactions, and changing conditions of the pelvic floor muscles, are very important.
Periodic occurrence and intensification of pain and lower urinary tract (transparent), sleep disorders and, often, significant erection function affects a man's physical and psychological condition.
Often, lower urinary tract symptoms in young and middle -aged men are due to inflammation in the prostate gland, however, given the age of the patient, it is always necessary to perform a differential diagnosis between adenoma and prostate cancer.
There are different opinions on chronic prostatitis pathogenesis, based on the various methods of treatment.The treatment of acute prostatitis depends on the pathogen identified and mainly includes antibacterial medicines that have the largest penetration into the prostate tissue.
Acute bacterial prostatitis requires parenteral administration of bacterial antibiotics such as aminoglycosides or third -generation cephalosporin.Treatment continues until the fever disappears and the amount of blood normalizes.In less severe cases, fluoroquinolones can be prescribed.The duration of treatment with fluoroquinolones for acute prostatitis is 2-4 weeks.
For chronic bacterial prostatitis and chronic pelvic inflammation syndrome, treatment is performed with fluoroquinolones or trimethoprim.Patients were then examined again and antibiotics were only continued in cases where microorganisms caused the disease, or if the patient had a positive effect on therapy.
The recommended treatment period for chronic prostatitis is 4-6 weeks or more.Urodynamic studies have shown increased uretral pressure.In this regard, it is noted that combined treatment with α-blockers and antibiotics is more effective than monotherapy antibiotic in chronic pelvic inflammation syndrome.When prescribing therapy courses, doctors should discuss with the patient's duration, possible side effects, as well as the need to monitor the effectiveness and safety of treatment.
Herbal medicine in the treatment of chronic prostatitis
The use of herbal preparations in the treatment of prostate disease has a long history.Evidence of the effectiveness and safety of herbal medicine has been empirically obtained.
Currently, the possibility of using herbal medicines should be determined by modern ideas on pathogenesis and the development of pathological processes, especially in the prostate gland.
Processes such as functional obstruction, unrest in the prostatic urethra, the pathological influence of commensal microorganisms, immune changes, disrupting normal metabolism.Some violations are inevitable leading to others.For example, chronic inflammation leads to cellular disorders and damage.
Usually, the body always produces incomplete oxidation products, called free radicals, increasing numbers under various pathological conditions, especially during inflammation.Disruption in the supply of oxygen to the tissue, where the rate of accumulation of active radical compounds (oxygen, nitrogen and radical chlorine) exceeds their neutralization rate, called oxidative stress.As a result, oxidative stress leads to tissue damage over time, including in the prostate gland.
Biochemistry has long been known about natural antioxidants: vitamins E, C and carotenoids, but they cannot seriously affect oxidative stress.In recent years, more attention has been given to bioflavonoids, which are more powerful in antioxidant activity than vitamin E, vitamin C and beta-carotene.In total, more than 6,000 bioflavonoids are known, where more than 3,000 are flavors and more than 700 isoflavons.About 2% of the amount of organic carbon produced by photosynthesis is synthesized by plants to flavonoids or other polyphenols.
Flavonoids protect growing -radiation, ultraviolet irradiation, oxidation, disease, infection, bacteria.One of the representatives of the medicine plant containing bioflavonoids is Hedysarum Abandonment, herbs from the family of legumes.These small plants, high 25-50 cm, bloom from June to August with small purple-violet flowers.
The forgotten pennyweed root contains quercetin flavonoids, saponins and other biological active ingredients.It is a quercetin derivative that has antioxidant activity and is effective in patients with chronic prostatitis, which is confirmed by clinical studies.
In addition to these properties, the catechin contained in the forgotten kopeck root has high P-Vitamin activity, strengthening the capillary walls and optimizing micro circulation.The forgotten pennyweed root has an adaptogenic properties, which also determines the values including plants in complex therapy of patients with chronic prostatitis.
Also containing flavonoids are knotweed (polygonum aviculare), annual herb weeds with small leaves, ellipses.The single stem that extends from the base of the root branches very well and produces a green shoot mass.These low -growing plants have many greenish flowers that do not make it in May.Knotweed also contains large amounts of ascorbic acid, vitamin K, and Provitamin A.
Products based on herbal knotweed have long been known in urological practice as they have diuretic, anti-gout and adaptogenic effects.The use of Commonweed and Knotweed combinations allows us to expect significant clinical effects.
Herbal medicines found in clinical practice, produced from commonweed (root and rhizome), as well as knotweed herbs, are the root tincture of the forgotten commonweed.
The biologically active ingredients included in the tincture contain natural antioxidants and ingredients that improve micro -circulation, which determines the ability of these herbs to reduce the severity of inflammation in the prostate gland and pain syndrome (pain and weight in the perineum, prostitution).
Increased blood circulation in the prostate reduces the severity of lower urinary tract symptoms (including frequent urination, difficulty, discomfort when clearing the bladder, poor urine flow and incomplete emptying of the bladder), and also improves the functioning of the cave artery.
Clinical efficacy of tincture from forgotten kopeck root
The effectiveness of tincture has been studied in randomized studies of open comparison.The purpose of this study was to study the effects of herbal preparations on dynamic pain syndrome, objective data and laboratory parameters in patients with chronic prostatitis.
In addition to studying complaints and medical history, the diagnosis has been confirmed by a prostate secretion laboratory test in the form of pure or in the urine.In groups in line with active control, the effectiveness, safety and tolerance of the drug in patients with chronic prostatitis are evaluated.
To protest the symptoms of symptoms, the National Health Institute of Health Prostatitis Index (NIH-CPSI), urinary diary analysis, and comparison of laboratory data.In patients, urological diseases can be accompanied by the same symptoms (benign hyperplasia, prostate cancer), pathological changes in the nervous system and gastrointestinal tract are excluded.
Long prostatitis courses with periodic severity affect emotional and sexual areas.Observations and changes in the function of erection on the background of chronic prostatitis in patients who receive the drug are also performed using standard questionnaires.In parallel, drug safety is evaluated compared to other herbal medicines.
To explain the effective dosage of forgotten pennyweed roots, the patient is divided into two groups.The first group, consisting of 30 people, receives 1 teaspoon of color 3 times a day.The second group patient, who also consists of 30 people, takes 2 teaspoons 3 teaspoons a day.
Distribution of patients into groups has been carried out using simple random methods, which allows to study the effects of drugs in homogeneous groups.Red root is added to an empty stomach, at least 30 minutes before meals.Before use, the bottle with the drug was shaken, and one dose was dissolved in 1/3 glass of water.The duration of treatment is 30 days.
The control group of 20 patients diagnosed with chronic prostatitis receives treatment with the preparation of other herbs for the same period.Criteria for the effectiveness in groups using tincture 1 teaspoon 3 times a day, 2 teaspoons 3 times a day or taking comparative drugs is a change in clinical symptoms based on patient survey, questionnaire data and urinary diary.All including patients complete the study.
The average age of patients in the first group, who received forgotten kopeck roots, 1 teaspoon 3 times a day, was 45.5 (37-56) years (hereafter median, and the 25th and 75th percentiles were shown).The average age of patients in the second group, who took 2 teaspoons of tincture 3 times a day, was 45.5 (33-55) years.The average age of patients in the control group is 48 (36-59) years.
There was no statistically significant difference between groups (p = 0.63) (after variance analysis was used).It should be noted that chronic prostatitis has been identified in the most active and working people, where the preservation of erection and reproduction function is very important.Of all patients included in this study, 26 (32.5%) have a history of sexually transmitted diseases.The distribution of such patients in the group is the same.
Prior to prescribing Tincture Plus, 57 (71.3%) patients received treatment for chronic prostatitis.Often these are antibacterial therapy and/or α-blockers.The distribution of patients who previously received treatment, as well as the type of treatment, did not differ significantly between groups, which confirmed modern ideas on pathogenesis and, thus, chronic prostatitis treatment methods.
To objectively assess their symptoms and severity, as well as the quality of life of the patient, the NIH-CPSi scale is used, which is recommended for basic assessment and to monitor the patient's condition.Initially, the level of pain according to the NIH-CPSI scale before treatment in the group receiving the pennywort root, 1 teaspoon 3 times a day, was 13 (10-15) eyes;In a group receiving tincture 2 tablespoons 3 times a day - 12 (10-15) points.In the control group, this indicator is 13 (10-15) points.The severity of the pain between groups does not have a significant significant difference (p = 0.846).
The group of patients is homogeneous in localization and severity of pain, which is very important given the various clinical manifestations of the disease.
Since urinary tract disorders, namely, bladder obstruction, detrusor-sphincter dyssynergia, increased pressure in the prostatic urethra lumen and intraprostatic reflux, play an important role in the right and repetitive causes.Initially, in the first group of this indicator, according to the NIH-CPSI scale, 2 (1-3) points, in the second group 2 (1-3) points and in control of 2 (1-3) points.
The severity of urinary tract disorders is significantly different from the group (p = 0.937).The study group is homogeneous with regard to transparent.There is no difference between groups in urinary diary analysis.It can be said with a reasonable belief that transparent is associated with prostate disease, not with disruption of bladder function or water balance.
The maximum urine flow rate, according to uroflowmetry, in the first group is 13.3 (11.8-14.2) ml/s, in the second group-13.2 (12.1-14.0) ml/s, and in the control group-13.0 (11.8-14.6) ml/s.There was no statistically significant difference in this indicator between groups (p = 0.996).The amount of urine in the first, second and control was 23.0 (20-26), 23 (18-25) and 20 (16.5-24) ml, respectively.The group of patients is also not different in this indicator (p = 0.175).
It can be stated that there are no reservoir disorders and the function of bladder transplantation detected in patients with chronic prostatitis in the study group, however, the existing translation allows us to suspect the source of pathological symptoms accurately at the prostatic urethra level.
The patient's subjective perception of chronic prostatitis symptoms is also very important.Various uncomfortable sensations -different, exposed to repetition, often unpredictable, disrupting normal human life.This not only affects their mood, but also their social activities.That is why the study of quality of life, which depends on the severity of the disease, relapse and its consequences, also serves as a criterion for the effectiveness of the treatment.
Before the treatment is prescribed, in the group receiving red root tincture plus 1 teaspoon 3 times a day, the quality of life, according to the questionnaire, is evaluated at 6 (5-9) in the group receiving 2 tablespoons tinctures 3 times a day-at 8 (6-9) there was no statistically significant difference between groups for this indicator (p = 0.22).
The total score on the NIH-CPSI scale in the first group was 22 (19-25), in the second-23 (19-25) group, and in control-22 (18-25) (p = 0.801).Therefore, the groups are homogeneous not only in terms of the number of scores on the symptoms of chronic prostatitis symptoms, but also in terms of their components.All patients answer questions about the men's copulative function scale (MCF).In the first group the indicator is 31 (23-41) points, at the second point-34 (27-39), in the third point-34 (26-37).The effects of chronic prostatitis on erectile function are also the subject of the study.
In the three groups, the value range is quite broad.This indicates the individual level of a man's response to his symptoms and disorders.However, the distribution of patients with chronic prostatitis with different erection functioning conditions into the group before treatment is not different (p = 0.967).Therefore, at the beginning of the study, it is possible to form three groups of patients with chronic prostatitis, which is homogeneous at age, type and severity of clinical symptoms, which affect the quality of life.At the same time, reservoir disruption and bladder transplant function are excluded.
After 30 days of treatment, symptoms are evaluated in the formed group.In a group of patients receiving forgotten pennyweed roots, 1 teaspoon 3 times a day, according to control questionnaire, decreased frequency and severity of pain and discomfort recorded by 51%.When taking a 2 teaspoon tincture 3 times a day, the severity of the symptoms of 55% was observed.
In the control group, pathological symptoms decreased by 37%.The difference between three groups of patients is statistically significant (p = 0.029).However, there is no statistically significant difference between the first and second groups.Therefore, it is possible to achieve significant clinical effects with a minimum dose of the drug.In addition, statistically significant differences remain in the reduction of pathological symptoms when evaluating each group that consumes the root of the forgotten kopeck, compared to control.
According to the survey, there is an increase in urinary performance in patients with chronic prostatitis during treatment, but the difference is not statistically significant either between groups receiving pennywort roots in different doses, and compared to control groups.
When analyzing urinary diary data obtained after treatment, there are also statistically significant differences in the three groups.According to the results of uroflowmetry control, the maximum urinary tract increase is recorded in all groups, ranging from 5 to 12%.The amount of waste urine in patients receiving drugs in various doses, and in patients receiving treatment with herbal reference drugs, decreases by 4-6%.The differences between groups are not statistically significant.
This fact can be explained by a relatively short period of use, as well as the absence of components in red roots coupled with tincture that will have a similar effect to α-adrenergic and 5α-reductase inhibitors.The main active ingredient of the drug is a compound of bioflavonoid groups, which have a variety of effects, especially antioxidant and anti-inflammatory effects.
According to the Control Exam, based on repeated inquiries, the improvement in the quality of life indicators is recorded after 30 days of treatment.In the first group, this figure changed by 55%, at the second - 59%, and in the control group - by 39%.Differences in Dynamics Changes in quality of life during the use of forgotten kopeck root tincture and in statistically significant control groups (p = 0.008).
Keep in mind that groups receiving tinctures in different doses are not different from the dynamics of quality of life.Analysis of changes in quality of life confirms the adaptogenic effects of herbal preparation components containing forgotten kopk and knotweed.The NIH-CPSI number score decreases in all three groups after 30 days of treatment.In the first group there was a 50%decrease, in the second - 52%, and in the third - 29%.At the same time, the same trend is recorded as in the analysis of other clues.
The difference is statistically significant between patients receiving forgotten kopeck roots and patients in the control group, and no difference between groups receives drugs in different doses.
Third -three patients showed a similar increase in the total score on the ICF (P = 0.455) questionnaire.Changes in indicators in all groups are no more than 10%.There were no statistically significant differences between groups.
Improvements in copulatory function may be associated primarily with decreased symptoms of prostate gland pathology, transparent decreases, adaptogenic properties and improved micro -circulation.The state of the prostate gland during the use of herbal preparations is interesting.This is reflected in the analysis of repeated prostate secretions.
If at first the group of patients does not differ from the presence and number of leukocytes in prostate secretion (p = 0.528), then after 30 days of treatment in all groups there is a decrease in the severity of the inflammatory process.In a group that receives forgotten pennyweed root tincture, statistical decrease (p = 0.028) in the number of leukocytes is recorded compared to the control group.Changing the dose of the drug does not affect the dynamics of decreased leukocytes.
According to a prostate secretion study, a significant decrease in the severity of the inflammatory process and the improvement of the functioning of the prostate gland has been established.
Different herbal remedies contain a set of individual bioflavonoids with different activities.Apparently, the combination of rhizomes and roots of commonweed and knotweed contains bioflavonoids that are active on the effects of oxidative stress in prostate tissue.This can be assumed based on the effectiveness of the drug and the absence of a dose -dependent difference.However, this assumption must be confirmed by further research.
Conclusion
Among the methods of treating prostatitis, the use of herbal preparations is important.The effectiveness of this drug group has been confirmed by clinical experience.However, conducting a randomized clinical test aimed at assessing the effectiveness of herbal preparations based on modern ideas on active principles allowing us to take a new approach to herbal medicine.
The efficacy of plant bioflavonoids is allowed by the theory of oxidative stress, according to which uncontrolled free radical oxidation products have the effects of damage to cells and cause many organ and system dysfunction.
Taking into account the above, it seems possible to conclude that herbal medicine uses a forgotten kopeck root tincture, a medical product with significant anti-inflammatory and antioxidant effects, is the most effective in the complex treatment of patients with chronic prostatitis and in monotherapy for the prevention of the disease.